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KMID : 0903519990420020166
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
1999 Volume.42 No. 2 p.166 ~ p.169
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Isolation of Monoamine Oxidase B Inhibitory Compound from the Leaves of Eucommia ulmoides Oliv.
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이동욱/Lee, Dong Wook
백남인/안은미/손형옥/권병목/한재택/Baek, Nam In/Ahn, Eun Mi/Sohn, Hyung Ok/Kwon, Byung Mok/Han, Jae Taek
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Abstract
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The repeated silica gel colum chromatographies of n-BuOH fraction obtained from MeOH extracts of Eucommia ulmoides leaves led to isolation of a flavonoid-glycoside inhibiting monoamine oxidase B activity. Its chemical structure was determined to be 3-Ο-[β-D-glucopyranosyl (1→2) β-D-xylopyranosyl] quercetin through interpretation of spectral data and adaptation of acid hydrolysis. The IC_(50) value of this compound in rat brain mitochondrial MAO-B inhibitory activity was evaluated to be 8.05 μmol/ℓ.
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